Episode Summary
In this episode of Leap Together, principal investigator and pain medicine physician Dr. Todd Bertoch breaks down what truly advances pain research; moving beyond an opioid-first mindset toward mechanism-targeted, multimodal analgesia. Drawing on decades at the bedside and more than a hundred trials, Dr. Bertoch explains why “zero pain” isn’t a realistic endpoint, how function and safety provide more meaningful patient-centric measures, and the design choices that make studies both faster and more inclusive.
You’ll hear practical guidance on opioid-sparing perioperative and chronic pain models, selecting endpoints patients can feel, and trimming nonessential procedures to reduce participant burden without sacrificing statistical sensitivity. Dr. Bertoch also shares site-level feasibility tips: align sponsors and PIs early, choose ePROs that matter, streamline visit schedules, and build recruitment pipelines that reflect real-world patients.
If you work in clinical operations, at a research site, or on the sponsor side, this conversation offers actionable steps to run safer, simpler, and more effective pain trials, and deliver results that translate to everyday care.
Listen now above or at: https://lpcur.com/LeapTogetherEp8
Leave a Reply